Associations with an altered risk of the nonresponse to methotrexate in JIA were observed for the alleles/genotypes of the loci IL10 rs1800872 (in girls) and NFKB1 rs28362491 (in girls); with an altered risk of the insufficient response to methotrexate in JIA - for the alleles/genotypes of the loci IL1B rs16944 (in boys), CTLA4 rs3087243 (in boys), NFKB1 rs28362491 (in girls), and the haplotype TNFA rs1800629*A - LTA rs909253*G (in girls) (Table 3). This evidence concerns the gene NFKB1 and juvenile idiopathic arthritis.