Associations for the IL1B rs16944 and NFKB1 rs28362491 polymorphic loci variants seem to be the most promising, since they allow to evaluate the efficacy prognosis simultaneously for two the most widely used disease-modifying antirheumatic drugs in the JIA treatment: methotrexate and etanercept. This evidence concerns the gene NFKB1 and juvenile idiopathic arthritis.