It was also noted that in the case of the absence of the response to methotrexate in patients with JIA, the IL2-IL21 rs6822844*TT and LTA rs909253*AG genotypes were nonsignificantly more common (IL2-IL21 rs6822844*TT: pcor = 0.054, LTA rs909253*AG: pcor = 0.098), and the statistically significant results were obtained for the IL2-IL21 rs6822844 locus when testing the recessive model of inheritance (TT vs. GG+GT, P = 0.017). The gene discussed is IL21; the disease is juvenile idiopathic arthritis.