RPS6KB1 and cholangiocarcinoma: Pang X et al demonstrated that celastrol targeted Akt/mTOR/P70S6K signaling pathway in endothelial cells.18 Kannaiyan et al found that celastrol induced inhibition of proliferation vis suppression of PI3K/Akt signaling pathways in RPMI‐8226 cells.22 Considering PI3K/Akt signaling pathways act as an essential role in CCA development, we put forward the hypothesis that celastrol have the potential to inhibit CCA cell growth and metastasis.