Pang X et al demonstrated that celastrol targeted Akt/mTOR/P70S6K signaling pathway in endothelial cells.18 Kannaiyan et al found that celastrol induced inhibition of proliferation vis suppression of PI3K/Akt signaling pathways in RPMI‐8226 cells.22 Considering PI3K/Akt signaling pathways act as an essential role in CCA development, we put forward the hypothesis that celastrol have the potential to inhibit CCA cell growth and metastasis. This evidence concerns the gene AKT1 and cholangiocarcinoma.