Although the exact mechanism leading to CCA has not been fully demonstrated, cumulative studies have shown that the phosphoinositide 3‐kinase (PI3K)/Akt plays an important role in the response of cells stimulated by external signals, and the abnormal activation of the PI3K/Akt pathway is closely related to the occurrence and development of malignant tumors, including CCA.21 Blocking multiple signaling pathways is the theoretical basis of many anticancer drugs. Here, AKT1 is linked to cholangiocarcinoma.