INS and cardiovascular disorder: Visceral fat accumulation has been shown to play important roles in the development of cardiovascular diseases.1, 2 Fat tissue is an endocrine organ producing adipocytokines that influence energy and lipid metabolism, insulin sensitivity, blood pressure, inflammation and angiogenesis.1 The well‐known adipocytokine, visfatin, was initially demonstrated to improve insulin sensitivity.3 Further researches4, 5 showed that visfatin expression increased by hypoxia, enhancing angiogenesis in adipocytes and breast cancer cells through hypoxia‐inducible factor‐1α (HIF‐1α).