Binding of LASP1 to the conserved leucine/isoleucine (LKIL) motif at the carboxy‐terminal domain of CXCR4 requires phosphorylation of LASP1 at S146 and stabilizes the chemokine receptor.14, 15 In breast cancer cells, receptor activation then results in the translocation of LASP1 to the nucleus and interference of the protein with the epigenetic machinery.16 This evidence concerns the gene CXCR4 and breast carcinoma.