A proposed mechanism for molecular relapse in CML patients involves leukaemic stem cell homing to the bone marrow, mediated through the chemokine receptor 4 (CXCR4)‐C‐X‐C motif chemokine 12 (CXCR12) axis. This evidence concerns the gene CXCR4 and chronic myelogenous leukemia, BCR-ABL1 positive.