MMP substrates also include adhesion molecules and apoptosis‐mediated factors that regulate cell adhesion and change the ability of tumour cells to metastasize.45 In addition, the expression of karyotype MMP‐1 is detected in the stromal cells of breast cancer, and the total expression of MMP‐1 in breast cancer patients is associated with a poor survival rate. Here, MMP1 is linked to breast cancer.