VEGF‐C and VEGF‐D combined with VEGFR‐2 and VEGFR‐3 regulate angiogenesis and participate in lymphangiogenesis.39 In a study of breast cancer, patients with higher VEGF expression have a poorer prognosis and earlier recurrence than tumour patients with lower VEGF expression after surgery.40 This evidence concerns the gene VEGFA and breast carcinoma.