PPAR regulates several biological processes in obesity, including inflammation, lipid metabolism and glucose metabolism.28 In the regulation of lipid metabolism, it mainly plays a role in affecting lipogenesis, lipid storage and adaptive heat production.29 PPAR‐α improves insulin sensitivity and β‐cell function by reducing obesity, hepatic steatosis, plasma‐free fatty acids and triglycerides.30 Furthermore, recent studies have shown that PPAR‐α deficiency will reduce the average area of pancreatic β‐cells and reduce insulin secretion caused by glucose. Here, PPARA is linked to obesity due to melanocortin 4 receptor deficiency.