Due to the beneficial effects of A platensis on angiogenesis observed in the in vitro assays, we focused on an evaluation of the vascularization of tumours, as measured by the expression of endothelial marker CD31.21 Indeed, as compared to the controls, the expression of CD31 was more than 2X lower in the tumours of animals treated with A platensis (45% of controls, P < .01, Figure 2A). The gene discussed is PECAM1; the disease is neoplasm.