RAF1 and familial pancreatic carcinoma: In addition, we found that A platensis extract does not affect ERK activity in BxPC3 pancreatic cancer cells that contain constitutively active B‐RAF due to in‐frame deletion.49 As active Ras promotes Raf activation by direct association, these data indicate that A platensis most likely inhibits the ERK pathway activation at the level or upstream of Ras or that it affects Ras‐mediated activation of Raf.