Previously, there were only limited studies on miR‐328‐3p reporting that miR‐328‐3p could enhance the radiosensitivity of non‐small cell lung cancer cells23 and osteosarcoma.24 Moreover, miR‐328‐3p exerts as an anti‐tumour miR with potential impeding osteosarcoma cell migration through regulation of MMP16.25 These studies have strongly suggested that miR‐328‐3p may play important role in cancer development. This evidence concerns the gene MMP16 and osteosarcoma.