At the same time, immunohistochemical staining and ELISA provided data to show that the levels of TNF‐α and IL‐6 in tumour tissues and serum were decreased in response to silencing of hsa_circRNA_002178 or overexpression of miR‐328‐3p, but increased in response to overexpression of hsa_circRNA_002178 (P < .05). This evidence concerns the gene IL6 and neoplasm.