To explore this possibility, we used lung EC isolated from both WT and Id1 KO mice and pharmacological treatment of a microvascular EC line to demonstrate that hyperglycemia results in increased ROS in KO cells and that low‐level oxidative stress in KO cells and cells with pharmacological decreases in Id1 expression results in an increased DNA damage response, p53 expression, and markers of cell senescence. Here, ID1 is linked to Hyperglycemia.