Given the prosurvival effects of increased Id1 expression following oxidative stress, we sought to determine the effects of streptozotocin (stz)‐induced hyperglycemia on endothelial Id1 expression and the effect of Id1 knockout (KO) on EC response to hyperglycemia, and the resulting effect on the development of nephropathy and the mechanisms by which this may occur. The gene discussed is ID1; the disease is kidney disorder.