APC and adenocarcinoma: APC mutation leads to intestinal carcinogenesis along the adenoma‐adenocarcinoma sequence ultimately to invasive cancer, and this is more in line with the progression of CRC Apcmin/+ mice which carried a germline mutation at codon 850 of the Apc gene and spontaneously developed intestinal adenoma were used in our study.14, 15, 16, 17 In addition, we explored the mechanism of innate immunity and the role of microbiota different from previous study.