Mice with FGFRL1 knockout are born normally but die after birth because of hypoplastic diaphragm at once.28 A patient was diagnosed with Antley‐Bixler syndrome caused by a frameshift mutation in the FGFRL1 gene on chromosome 4p16.29 Emerging evidence has demonstrated that FGFRL1 is related to tumour occurrence, development and metastasis, such as prostate cancer, gastric cancer, ovarian cancer and others.11, 12, 13, 14, 15, 16 But the mechanism of FGFRL1 in the drug resistance of SCLC is still unclear. This evidence concerns the gene FGFRL1 and Familial prostate cancer.