AKT1 and gastrointestinal stromal tumor: Accumulating evidence indicates that apoptosis and autophagy share common regulatory elements within oncogenic pathways activated by RTKs, including the PI3K/AKT/mTOR pathway.42, 43 To date, few studies have described the autophagy‐modulating role of BRD4 inhibition in tumour cells.44 One such study reported that glioma cells treated with JQ1 exhibited increased autophagic activity.45, 46, 47 In imatinib‐resistant GIST cells, increased expression of LC3‐II, a widely accepted autophagic marker, was inducible by JQ1, and its level was even higher upon combined treatment with JQ1 and imatinib.