In this context, JQ1‐induced apoptosis in GIST cells is potentially linked to AKT inactivation, given that BRD4 inhibition may perturb the membranous lipid rafts needed for the proper subcellular localization of proteins involved in signal transduction, including proteins in the antiapoptotic PI3K/AKT/mTOR pathway. This evidence concerns the gene MTOR and gastrointestinal stromal tumor.