A synthetic analogue of cerulenin, JQ1, has been shown to potently inhibit BRD4 and suppress the tumour growth of various human cancers in vitro and in vivo.24 However, the therapeutic potential and molecular underpinnings of JQ1 remain unexplored in GIST, especially in regard to crosstalk with KIT‐elicited signal transduction. This evidence concerns the gene KIT and gastrointestinal stromal tumor.