AKT1 and gastrointestinal stromal tumor: Specifically, the relevant issues regarding JQ1‐induced autophagy include its potential dependency on AKT, engagement of KIT expression and activation and the resultant cytoprotection to maintain energy homeostasis versus cytotoxicity to promote cellular death under nutrient deprivation.48 A better understanding of these aspects will help decipher the possible benefits or detriments of autophagic inhibition in GIST cell growth in combined therapy against BRD4 and KIT.