Yin Yang 1 is a well‐known transcription activator, and former study has demonstrated that high glucose facilitated the translocation of YY1 from cytoplasm to the nucleus of tubular epithelial cells and aggravated diabetes.29 Hence, we deduced that HG treatment might also influence YY1 in HPCs and therefore the binding between YY1 and SPAG5‐AS1/SPAG5 promoter was increased, and this observation indicated that YY1 might be responsible for the HG‐caused induction of SPAG5‐AS1 and SPAG5 in HPCs. Here, SPAG5 is linked to diabetes mellitus.