USP14 is a regulator of de‐ubiquitination and has been reported to be activated through AKT/mTOR pathway and negatively regulate autophagy by K48 de‐ubiquitination in neurodegenerative diseases.32 Hence, we speculated that SPAG5‐AS1 might regulate SPAG5 through USP14. This evidence concerns the gene AKT1 and neurodegenerative disease.