FN1 and malignant colon neoplasm: Indeed, with NOD1 activation, we observed a significant increase in in vitro static adhesion of human colon cancer cells HT29 to fibronectin (2-fold), collagen I (2-fold) and collagen IV (1.5-fold) compared to baseline DMSO control (P < 0.0001) (Fig. 4A and 4B).