To examine the influence of CAF-secreted exosomal SNHG3 on tumor cell proliferation through the modulation of the expression of miR-330 and PKM, MD-MBA-453 cells were co-treated with exosomes secreted from CAFs transfected by si-SNHG3 or si-control, concurrently with the transfection of anti-miR-330, anti-miR-control, PKM, or Vector. The gene discussed is PKM; the disease is neoplasm.