For example, Figure 4B and C shows the expression pattern of two such genes, Phosphoenolpyruvate Carboxykinase 1 (PCK1, known to be downregulated in KIRC (81) and general marker of renal failure (82)) and Chromosome 10 Open Reading Frame 99 (C10orf99, a known colon cancer inhibitor (83), and positive marker of KIRC (84)), in KIRC and KIRP. This evidence concerns the gene PCK1 and Renal insufficiency.