In contrast, GPC3 is downregulated in nine tumor types (BRCA, COAD, ESCA, KIRC, KIRP, LUAD, LUSC, THCA and UCEC) and unchanged in three tumor types (KICH, STAD and PRAD) (Figure 3A and B; Supplementary File 5). The gene discussed is GPC3; the disease is neoplasm.