In addition, intraperitoneal infection of mice with B. abortus allows corroborating in vitro findings, among them the role of BPE005 in the induction of liver fibrosis revealed by the increase in collagen deposition in liver and the expression of TGF-β in HSC, as well as the presence of lymphocytic inflammatory infiltrate (Arriola Benitez et al., 2013, 2016). The gene discussed is TGFB1; the disease is Hepatic fibrosis.