CD4 and infection: < 100 cells/mm3) and give past medical histories that suggest advanced immune suppression, namely, previous TB, recurrent bacterial and other infections and unexplained weight loss.23 Despite adherence to therapy, INRs remain at an increased risk of disease and death notwithstanding years of documented viral suppression.24 No dependable treatment currently reconstitutes the blood compartment with CD4 cells in this group of patients.