Totally, 20 mice generated tumors (5 for each group), and our results revealed that xenografts of HCC cells with macrophages (THP-1) had more metastasis than no coculture group, and oemiR-149-5p can partly reverse in vivo function of macrophages (Fig. 6A-B), and the IHC data of MMP9 expression also confirmed our conclusions(Figure S1C). This evidence concerns the gene MMP9 and hepatocellular carcinoma.