We also demonstrated that TRIM67 promotes the proliferation, migration, invasion and EMT of NSCLC cells through the Notch pathway and the expression of downstream proteins such as RhoA, RhoC, MMP-9, P21, c-myc, and EMT-related markers 17, 20, 21, thereby influencing the malignant behavior of tumor cells. The gene discussed is RHOC; the disease is neoplasm.