Ze Zhang et al used WGCNA and found out 12 key genes in head and neck squamous cell carcinoma, which were TIMP2, MIR198, LAMA4, FAM198B, MIR4649, COL5A1, COL1A2, OLFML2B, MMP2, FBN1, ADAM12, and PDGFRB 18. This evidence concerns the gene PDGFRB and head and neck squamous cell carcinoma.