EGFR and neoplasm: The mechanism research about how TF is of great importance in the development of cancer demonstrated that TF could regulate MAPK, PI3K 20 and EGFR pathways, and this process was promoted during epithelial-to-mesenchymal transition (EMT) 21, thus inducing the release of vascular endothelial growth Factor (VEGF) from tumor 22-24.