We found that high expression of MMP-14 may be an independent poor prognostic factor (OS, HR = 1.98, 95% Cl: 1.76-2.22, P < 0.001 and DFS/PFS, HR = 3.61, 95% Cl: 2.39-5.43, P < 0.001), particularly in multivariate analysis group (HR = 2.64, 95% CI: 1.95-3.58, P < 0.001), and patients with gastric cancer (HR = 2.21, 95% CI: 1.76-2.77, P < 0.001) and HCC (HR = 2.14, 95% CI: 1.35-2.19, P < 0.001) and oral cancer(HR = 1.69, 95% CI: 1.30-3.20, P < 0.001). Here, MMP14 is linked to hepatocellular carcinoma.