Survival analysis of a Cancer Genome Atlas (TCGA) lung cancer dataset demonstrated that high expression of acetylcholine receptors (AChRs) gene family such as CHRM2, CHRM3, CHRNA1, CHRNA2, CHRNA6, CHRNB3, or CHRNE is associated with favorable prognosis in NSCLC adenocarcinoma, but that of CHRNA5/α5nAChR or CHRNA7/α7nAChR is associated with an unfavorable prognosis 41. This evidence concerns the gene CHRNA5 and lung carcinoma.