Thus, in this study, our data discovered that PRPS2 knockdown significantly upregulated cyclin-dependent kinase inhibitor p27 but downregulated G1/S-specific protein cyclin D1 both in PC3 and DU145 cells, indicated that PRPS2 may be a potential druggable target for c-MYC responsive cell cycle checkpoint pathway in PCa. Here, MYC is linked to posterior cortical atrophy.