In this study, RBP4 levels were significantly and positively associated with BG0, BG30, BG120, BG180, INS0, CP0, HOMA-IR and HGB in females with obesity, and also significantly and positively associated with HOMA-IR and negatively with Matsuda index in males with obesity. The gene discussed is RBP4; the disease is obesity due to melanocortin 4 receptor deficiency.