SOAT1 and heart failure: This study also showed that AG 1296 (PDGF receptor inhibitor), S3I 201 (STAT3 inhibitor), AG-490 (JAK2 selective inhibitor), and filgotinib (JAK-inhibitor) attenuated the profibrotic effects of PDGF highlighting the central role of the JAK-STAT pathway in the development of atrial fibrosis and AF in heart failure (Chen, 2017).