For example, its transmembrane/TGFβ, cell stress response/DNA damage and chromosome/M-phase related molecular functions are abundant in the genes of recurrent MSI, and the occurrence of frameshift MSI in TGFBR2 is more common in Colon adenocarcinoma (COAD) and Stomach adenocarcinoma (STAD) than in Uterine corpus endometrial carcinoma (UCEC), indicating that specific tumor environment is conducive to the occurrence of MSI events [24]. The gene discussed is TGFBR2; the disease is gastric adenocarcinoma.