GDF9‐deficient mice develop primordial follicles, but follicular development is arrested at the stage with one or two layers of granulosa cells, which leads to complete infertility.20 BMP15‐null female mice are subfertile and usually have minimal ovarian histopathological defects, but demonstrate decreased rates of ovulation and fertilization.21 GDF9 is essential for normal folliculogenesis in sheep.106 Immunization against GDF9 and BMP15 reduced antral follicles in cattle.107. Here, GDF9 is linked to Infertility.