To examine the effect of simultaneous inactivation of all Hsp90 paralogs in cancer cells, we treated HeLa cells with Hsp90 inhibitors (to inactivate Hsp90s localized in the cytoplasm and ER) and gamitrinib (to inactivate the mitochondrial pool of Hsp90s, including TRAP1)31,32. The gene discussed is HSP90AB1; the disease is cancer.