USPs have specifically been reported to play roles in cancers such as prostate cancer (USP2a, USP7, USP10)39–41, ovarian cancer (USP15, USP36)42,43, glioblastoma (USP9X)44, and colorectal cancer (USP4, USP7)45,46. This evidence concerns the gene USP7 and Familial prostate cancer.