PROS1 and cancer: In our previous bioinformatic analysis, the expression of lncRNA RP11-328K4.1 and PROS1 mRNA was downregulated in cancer tissues compared to that in adjacent normal tissues in ICC, while the expression of miRNA hsa-miR-27a-3p was upregulated in ICC cancer tissues, which was consistent with the mechanism of action and expression trends between ceRNA and miRNA in the ceRNA hypothesis.