PROS1 and intrahepatic cholangiocarcinoma: Based on the ceRNET theory and the GEO microarray database, for the first time, we constructed ICC-related ceRNETs by using a bioinformatics method, subsequently screened the core regulatory pathway related to the pathogenesis of ICC:RP11-328K4.1-hsa-miR-27a-3p-PROS1, and finally conducted preliminary experimental validation of the expression levels, expression trends and regulatory relationships of the screened ceRNAs of this core regulatory pathway by using molecular experiments.