In conclusion, this study showed that catechin relieved H/R‐induced myocardial cell apoptosis through regulating CREB/lncRNA MIAT/Akt/Gsk‐3β pathway, which clarified the underlying mechanism of catechin in inhibiting H/R‐induced myocardial cell apoptosis, and might provide potential targets for relieving MI/R injury. Here, CREB1 is linked to myocardial infarction.