Recently, studies have shown that abnormally expressed lncRNAs were closely related with mitochondrial dysfunction.39 For example, lncRNA HOTAIR knockdown increased ROS production and caused mitochondrial swelling in HeLa cells, indicating lncRNA HOTAIR knockdown led to mitochondrial dysfunction.40 Overexpression of lncRNA UIHTC enhanced mitochondrial function to protect against myocardial infarction.41 These findings indicated lncRNAs exerted a critical role in mitochondrial dysfunction. The gene discussed is HOTAIR; the disease is myocardial infarction.