BECN1 and Miyoshi myopathy: As shown in Fig. 5C,D, compared to nontreated controls, NEK2‐OE KMS11 or RPMI 8226 MM cell lines showed only a slight decrease in their capacity to form colonies, while those cells expressing BECN1‐shRNA showed a significant decrease in colony formation when treated with the same dose of BTZ, indicating that silence of Beclin‐1 prevents BTZ resistance in NEK2‐OE MM cell lines.