After 3–5 days from fever onset, SD patients manifest severe plasma leakage leading to: shock, fluid accumulation with respiratory distress and severe bleeding with severe organ involvement (liver: aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≤1000, central nervous system (CNS): impaired consciousness, heart and other organs). This evidence concerns the gene GPT and Salla disease.