The Wnt signaling pathway plays important roles in the carcinogenesis of several types of cancers, especially colon cancer,.23 HOTAIR was shown to activate Wnt pathway through inhibition of WIF‐1 expression,17 and could participate in the drug resistance.24 Furthermore, STAT3 (signaling transducer and activator of transcription 3) has been proved to regulate the activity of HOTAIR, and influence the biological functions of cervical cancer.25 In addition, STAT3 could also promote epithelial‐mesenchymal transition (EMT) in colon cancer, thus contributing to the cancer metastasis.26 This evidence concerns the gene HOTAIR and malignant colon neoplasm.