Xenograft mice model is widely used in the investigation of the underlying mechanism of tumorigenesis and drug responses of colon cancer.36, 37, 38, 39, 40 Our results showed that propofol treatment or knockdown of lncRNA HOTAIR decreased tumor volume and weight, and inhibited expression of STAT3 and lncRNA HOTAIR, while WIF‐1 expression was enhanced. Here, HOTAIR is linked to malignant colon neoplasm.