As a key transcription factor, c‐Myc is frequently overexpressed in human cancers, including CC,26 and it can transcriptionally activate a cohort of oncogenes by directly binding to the ‘E‐box’ motifs on their promoters.27 Up to now, many lncRNAs were reported to be regulated by c‐Myc, such as FGF13‐AS1,28 RHPN1‐AS1,29 NEAT1,30 and Linc00176.31 In this study, we found that there are two E‐box motifs on ARAP1‐AS1 promoter, and the results of luciferase reporter and ChIP assays revealed that Site 1 located on −733 to −722 region conferred c‐Myc–dependent transcriptional activation of ARAP1‐AS1. The gene discussed is PTGDR; the disease is cancer.