A first subgroup analysis of this ccRCC entity was reported by Giraldo et al. While patients with “normal” oligoclonal CD8+ T-cell texture had a good clinical outcome, patients with polyclonal CD8+ T-cell texture showed a limited cytotoxic capacity and presumably did not recognize any relevant tumor-associated antigens (TAAs) [24]. This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.