Our in vivo analysis of the NAIP/NLRC4-mediated defense focused on the S. Tm infection dynamics during the first 24h after orogastric inoculation in the Streptomycin pretreated mouse model.56 Due to its highly reproducible, fast and robust kinetics, this infection setup is ideally suited to study innate immune restriction of enteropathogen dissemination to systemic sites. The gene discussed is NLRC4; the disease is infection.