NLRC4 and infection: This is in line with earlier work indicating that sipAsopBsopEsopE2-mediated epithelium invasion is the key trigger of acute mucosal inflammation.72,73 Importantly, when infecting with S. TmΔ4,, we did not observe any effect of the ablation of NLRC4 on the mLN infection dynamics and cecal lumen colonization (Fig. 3b, S2I).