KEAP1 and neoplasm: In contrast to the control tumor xenografts of Huh7 origin, a reduction in Ki67 and Nrf2 expression, and upregulation of Keap1 expression were observed in the tumor xenografts derived from Huh7 cells with TRIM25 depleted (Fig. 6e, f), suggesting that TRIM25-induced Keap1-Nrf2 pathway plays a vital role in HCC growth.