Moreover, upregulation of TRIM25 is correlated with high Nrf2 expression and low Keap1 expression in both tumor xenograft and HCC specimens, suggested that TRIM25 upregulation may be in part responsible for Nrf2 activation in HCC and perhaps also other tumors that do not harbor mutations in Nrf2 or Keap1. This evidence concerns the gene KEAP1 and hepatocellular carcinoma.