Relevant examples included alkaline phosphatase Alpl (the enzyme assayed in Fig. 1d and Supplementary Fig. 1c–e), epigenetic regulator Cdyl2, activin receptor Acvr1b/Alk4, nuclear receptor co-activator Dcaf6/NRIP, and a conserved RAGNYA domain protein Ammecr1 mutated in the Alport syndrome with mental retardation, midface hypoplasia, and elliptocytosis43–47. Here, ALPL is linked to Alport syndrome.