In addition, findings that MUC1-C contributes to induction of (i) the BRN2 neural TF39, and (ii) MYCN, EZH2 and selected NE markers (ASCL1, AUROKA and SYP), which have been associated with progression to NEPC8,12, provided further support for the notion that MUC1-C drives NE differentiation in PC. Here, ASCL1 is linked to pachyonychia congenita.