The promoter region of the evolutionarily highly conserved B4GALT1 gene encoding β4GalT1 is rich in enhancer sequences for transcription factors associated with thrombopoiesis, such as E2F1, cell identity regulatory programs, and hematopoietic tumor drug resistance27,28. Here, B4GALT1 is linked to hematopoietic and lymphoid cell neoplasm.