The largest networks each contained in excess of 100 genes, with the largest centred around LDHC. This is a germ-cell specific gene (www.proteinatlas.org)32, typically expressed only in the testis, however, multiple splice variants of the gene have also been found to be significantly expressed in a wide range of tumours including melanoma, breast, colon, prostate, lung, renal, ovarian, thyroid and cervical cancers27. This evidence concerns the gene LDHC and melanoma.