As one published abstract hints that Mlkl-deficiency does not improve atherosclerosis (Rasheed et al., 2018), and as we were unable to detect p-MLKL in the atherosclerotic plaques we analyzed (Fig. 5A,B and Fig. S6), we propose that necroptosis contributes minimally to atherosclerosis progression and to the anti-inflammatory roles we have defined for RIPK3 in this study. Here, MLKL is linked to atherosclerosis.