CST4 and amyloidosis: Of other hereditary systemic amyloidoses, ATTR amyloidosis leads to death on average in 10 years after the disease onset [49], cystatine (ACys) amyloidosis before the age of 40 years [50], fibrinogen (AFib) amyloidosis within a median of 15.2 years after disease manifestation [51], and in lysozyme (ALys) amyloidosis the survival varies remarkably from 1 to 20 years after disease onset [52].