In 74 PC samples, proteins were overexpressed in 67.6% (50/74) of MSI2, 52.7% (39/74) of ZEB1, 39.2% (29/74) of E-cad, 51.3% (38/74) of c-Myc and 29.7% (22/74) of vimentin by IHC assays, respectively (Table 1). The gene discussed is ZEB1; the disease is pachyonychia congenita.