CCL2 and Parkinson disease: These analyses showed that two biomarkers specifically correlated with disease progression in the PD group, i.e. monocyte chemoattractant protein 1 (MCP-1) positively correlated with HY progression (rho = 0.690, p = 0.003) and matrix metalloproteinase 10 (MMP-10) positively correlated with the UPDRS progression (rho = 0.651, p = 0.006) (Fig. 2).