PDK2 and autosomal dominant polycystic kidney disease: Another example is represented by the anti-miR-17, which suppresses miR-17 expression in kidney cysts, reducing their growth through indirect induction of Pdk1 and Pdk2 (Pyruvate dehydrogenase kinase isoform 1 and 2, respectively), thus demonstrating a promising therapeutic strategy for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) [193].