Inhibition of the immune response was also observed in the pathogenesis of pancreatic cancer, where exosomal miR-212-3p and miR-203 were transferred to dendritic cells inducing the downregulation of Regulatory factor-X Associated Protein (RFXAP) and TLR4 (Toll-Like Receptor 4), respectively, leading to suppression of the immune response of dendritic cells [177,178]. This evidence concerns the gene TLR4 and familial pancreatic carcinoma.