Another immunomodulatory mechanism is mediated by miR-145: it can be released in microvesicles from colorectal cancer cells to be transferred to tumor-associated macrophages (TAMs), where it downregulates the expression of Histone Deacetylase 11 (HDAC11), promoting their differentiation towards M2-like phenotypes and facilitating tumor progression [179]. This evidence concerns the gene HDAC11 and colorectal cancer.