Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by the presence of two neuropathological features, namely the senile plaques, consisting of β-Amyloid peptides (Aβ), and the Neurofibrillary Tangles (NFTs), that contain highly phosphorylated microtubule-associated protein Tau [102]. Here, MAPT is linked to Alzheimer disease.