Furthermore, many -3p miRNAs have important roles in physiology and pathophysiology, such as miR-455-3p which targets the 3′ UTR of PAK2 (P21-Activated Kinase 2), inhibiting the cartilage degeneration pathway in human osteoarthritis models both in in vitro and ex vivo experiments [43]. The gene discussed is PAK2; the disease is osteoarthritis.