Future research is needed to validate our findings by using additional L1CAM knockout cell cultures, by functional characterization of L1CAM cells from primary ovarian carcinoma cells, by mechanistic analysis of L1CAM-mediated regulation of cell stemness and radioresistance, as well as by validation of L1CAM expression levels as prognostic factors of the clinical outcome of ovarian carcinoma patients. Here, L1CAM is linked to ovarian carcinoma.